Collecting the pieces of the heterogeneity puzzle

While we advance in our conceptualization of NSC states, we are also actively investigating different sources of heterogeneity and signal integration mechanisms in adult NSCs. Our current projects aim to deepen our mechanistic understanding of the effects of Insulin/IGF, BMP/SMAD and MAPK signaling on NSC transitions. We are also investigating how HUWE1 and proteasomal activity change between active and quiescent NSCs.
One recurrent observation is the differential subcellular localization of key cellular components and signaling molecules between NSC states, which increases heterogeneity of the NSC pool. Furthermore, we have observed robust circadian rhythms within adult NSCs, introducing a temporal dimension to their heterogeneity.

One of our long-term aims is to comprehensively characterize the intercellular and extracellular cues provided by the neurogenic niche to NSCs. We are particularly interested in whether the distinctive, stereotyped morphology of NSCs underpins their function and long-term maintenance.